• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The present invention provides in a composite vaginal ring containing a safe and effective amount of a pharmaceutically active medicament which includes: a) a major supporting medicament-free vaginal ring consisting essentially of a physiolocigally acceptable synthetic resin and having at least a portion of the annular surface thereof adapted to mate with a corresponding minor, medicament-containing vaginal ring segment; and b) at least one minor, medicament-containing vaginal ring segment adapted to mate with the modified annular surface of said major supporting vaginal ring and consisting essentially of a safe and effective amount of a pharmaceutically active non-ionic, lipophilic drug dissolved or uniformly suspended in an elastomeric, cross-linked LTV linear dimethylpolysiloxane resin, the improvement wherein: at least one of the major supporting vaginal ring and the minor vaginal ring segment has a reniform or ellipsoidal cross section; or the major supporting vaginal ring is formed as a closed or inwardly open hollow-profile ring, as a closed or inwardly open hollow ring, as a hollow ring having a circular or reniform cross section, as a core-encased composite ring or as a sandwich element.
    公开号:SU833144A3
    申请号:SU772468507
    申请日:1977-04-08
    公开日:1981-05-23
    发明作者:Шепфлин-Хертвиг Гизела
    申请人:Шеринг Аг (Фирма)；
    IPC主号:
    专利说明:

    . The invention relates to medicine, namely to gynecology and obstetrics.
    According to the main patent "627736, a construction is known which contains a $ silicone vaginal ring of a shaped profile in cross section with one or more rings of a shaped profile in cross section fixed thereon containing the drug substance fl].
    However, this device requires sophisticated technology! manufacturing, which increases its cost.
    The purpose of the invention is to improve the manufacturability of the device. .about
    This goal is achieved by the fact that in the device the cross-sectional profile is made round or ellipsoidal or kidney-shaped, and the section itself is hollow or solid.
    In addition, the device has a coating of a drug substance on the outer surface.
    In FIG. 1 shows a contraceptive device, 25, with a kidney-shaped solid, cross-sectional profile} in FIG. 2 - the same, with a kidney-shaped profile of a hollow cross section; in “FIG. 3 - the same, with a round sectional sectional profile; in FIG. 4 - the same, with a round open, sectional cross-sectional profile; in FIG. 5-7 - embodiments of the device, with a round profile of a solid cross section and a coating of another synthetic material; in FIG. 8 - the same, with a round profile of a hollow cross section; in FIG. 9 - the same, with a round open profile of a hollow cross section; in FIG. 10 - the same, with an ellipsoidal profile of a continuous cross section; in FIG. 1'1 the same, with an ellipsoidal profile of a hollow cross section.
    The contraceptive device is a vaginal ring 1 made of a polymer material with one or two rings 2 with a drug: active substance placed on it, mainly on the outer surface (on the surface of a large diameter). Ring 1 can be made with a kidney-shaped profile of a solid or hollow cross section (Fig. 1 and 2).
    In addition, ring 1 may have a circular hollow cross-sectional profile, with the inner cavity of the ring provided with concentric septa 3 forming isolated sections (Figs. 3 and 4).
    Rings 1 with a circular hollow cross-sectional profile can be opened along the inner surface of a small diameter (Figs. 4 and 9). The inner cavity of such rings communicates with the environment.
    Ring 1 can be made with a round profile of a hollow cross section (Fig. 8), as well as with a round profile of a solid cross section and a coating 4 of a drug substance on the outer surface (Fig. 5, 6 and 7).
    In addition, ring 1 may have an ellipsoidal profile of a solid or hollow cross section (Figs. 10 and 11).
    The contraceptive device provides the return of drug-active substances for several (at least 20 three) weeks, regularly and constantly in the quantity required to achieve the desired biological effect.
    权利要求:
    Claims (2)
    [1]
    The invention relates to medicine, namely gynecology and obstetrics. According to main patent No. 627736, a known construction that contains a silicone vaginal ring of a shaped profile in cross section with one or several shaped profile rings fixed in it in cross section containing medicinal substance l. However, this device requires complicated manufacturing technology, which increases its cost. The purpose of the invention is to improve the manufacturability of the device. The goal is achieved by the fact that in the device the cross-section profile is made round or ellipsoidal or kidney-shaped, and the section itself is hollow or solid. In addition, the device has a coating of the drug substance on the outer surface. FIG. 1 shows a contraceptive device, with a kidney-shaped solid profile, of cross section j in FIG. 2 - the same, with a reniform profile of a hollow cross section; in “FIG. 3 - the same, with a round sectional cross-sectional profile; in fig. 4 - the same, with a round unclosed, sectional cross-sectional profile; in fig. 5-7 are embodiments of the device, with a round solid cross-sectional profile and a coating of another synthetic material; in fig. 8 - the same, with a round profile of hollow cross section; in fig. 9 - the same, with a round open profile of a hollow cross section; in fig. 10 - the same, with an ellipsoid profile of continuous cross section; in fig. 11 is the same, with an ellipsoidal profile of a hollow cross section. The contraceptive device is a vaginal ring 1 made of a polymeric material placed on it, mainly on the outer surface (on the surface of a large diameter), with one or two rings 2 with a medicinal: active substance. Ring 1 can be made with a kidney-shaped profile of solid or hollow cross-section (Fig. 1 and 2). In addition, the ring 1 may have a circular profile with a hollow cross section, the inner cavity of the ring being provided with concentric partitions 3 forming insulated sections (Fig. 3 and 4). Rings 1 with a round hollow cross-sectional profile may be open along the inner surface of a small diameter (Fig. 4 and 9). The internal cavity of such rings is in communication with the environment. Ring 1 can be made with a round profile of a hollow cross section (Fig. 8), as well as with a round profile of a continuous cross section and a coating 4 of the drug substance on the outer surface of FIG. 5, 6 and 7). In addition, the ring 1 may have an ellipsoidal profile of solid or hollow cross section (Figs. 10 and 11). A contraceptive device ensures the return of medicinal active substances for several (minimum three) weeks, regularly and continuously, in the quantity required to achieve the desired biological effect. Claim 1. Contraceptive device according to patent 627736, characterized in that, in order to maintain manufacturability, the cross-section profile is made round or ellipsoid or kidney-shaped, and the section itself is hollow or solid.
    [2]
    2. The device according to claim 1, characterized in that it has a coating of drug substance on the outer surface. Information sources taken into account during the examination 1. Patent. USSR 627736, cl. A 61 F 5/42, 1974.
    .".BUT..
    F
    类似技术:
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    同族专利:
    公开号 | 公开日
    DK157477A|1977-10-10|
    AU517915B2|1981-09-03|
    DE2616064A1|1977-10-20|
    IE44736B1|1982-03-10|
    HU176165B|1980-12-28|
    SE7703981L|1977-10-10|
    FR2347053B2|1980-07-04|
    IE44736L|1977-10-09|
    FR2347053A2|1977-11-04|
    BE853429R|1977-10-10|
    DD129162A6|1978-01-04|
    JPS52124798A|1977-10-20|
    CS197289B2|1980-04-30|
    AU2405577A|1978-10-12|
    NL7703651A|1977-10-11|
    CA1084792A|1980-09-02|
    IT1115641B|1986-02-03|
    GB1581474A|1980-12-17|
    ES457629A2|1978-11-16|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    FR2618329B1|1987-07-22|1997-03-28|Dow Corning Sa|METHOD OF MANUFACTURING A RING CAPABLE OF ENSURING THE RELEASE OF A THERAPEUTIC AGENT, AND RING MANUFACTURED BY THIS METHOD|
    FI95768C|1993-06-17|1996-03-25|Leiras Oy|Intravaginal dosing system|
    US6544546B1|1995-07-04|2003-04-08|Akzo Nobel, N.V.|Ring-shaped devices|
    JP2002513690A|1998-05-01|2002-05-14|エフイ−アイエンタープライジズ，リミティド|Injection molding manufacturing method for controlled release device|
    RU2591786C2|2010-11-12|2016-07-20|Дзе Юниверсити Оф Юта Рисерч Фаундейшн|Intravaginal device for controlled delivery of lubricants|
    CN104971414A|2014-04-01|2015-10-14|黄震山|Medicine sustained release device|
    CA2963034A1|2014-10-22|2016-04-28|International Partnership For Microbicides, Inc.|Platinum-catalyzed silicone drug delivery devices and methods of use thereof|
    US10918649B2|2019-06-21|2021-02-16|The Population Council, Inc.|System for providing birth control|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    DE19762616064|DE2616064A1|1976-04-09|1976-04-09|VAGINAL RING III|
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